INNOVATIVE PHARMACEUTICAL FORMULATIONS AND EXCIPIENTS FOR NASAL DELIVERY OF DRUGS TO TARGET THE SYSTEMIC CIRCULATION Ph.D. thesis
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چکیده
Article history:Received 9 July 2010Received in revised form 31 March 2011Accepted 21 May 2011Available online 1 June 2011
منابع مشابه
Absorption enhancing excipients in systemic nasal drug
Intranasal drug delivery is becoming an increasingly important form of drug administration for chronic and chronic-intermittent diseases. Important new applications currently in development include drugs for diabetes, osteoporosis, obesity, certain types of convulsive disorders, migraine headaches, symptomatic pain relief, nausea, and anxiety, among others. Transmucosal absorption across the na...
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The nasal route receives a great deal of attention as a non-invasive method for the systemic administration of drugs. For nasal delivery, specific formulations containing excipients are used. Because of the sensitive respiratory mucosa, not only the active ingredients, but also additives need to be tested in appropriate models for toxicity. The aim of the study was to measure the cytotoxicity o...
متن کاملTargeted Drug Delivery Systems Mediated Through Nasal Delivery for Improved Absorption: an Update
Address for correspondence Mr. Arshad Bashir Khan, Associate Professor, Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur Village, Carmelaram Post Varthur Hobli, Bangalore-560035, India. Phone No: 9740379897 E-mail: [email protected] ABSTRACT Purpose: This review article focuses on providing updated information about targeting the nasal mucosa for drug delivery....
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Background: The stratum corneum (SC) forms a difficult physical barrier for drugs to pass through the skin. Several strategies were developed to overcome this barrier. Optimization of topical drug formulations by selected excipients may facilitate the penetration of drugs through the SC into the viable skin cells and ultimately into the systemic circulation. Methods: Here, both the influence of...
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With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in their formulations. Pharmaceutical formulation development involves various components in addition to the active pharmaceutical ingredients. Nature has provided us a wide variety of materials to help improve and sustain the health of all living things either directly or ind...
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تاریخ انتشار 2012